The Reserve Bank of Australia uses LASSO to select predictors from a pool of 150+ monthly indicators when nowcasting GDP. The selected model typically retains 8--15 variables, which shifts in composition across vintages as the economic environment changes. The sparsity constraint forces the model to identify which signals are genuinely informative in each forecast round, avoiding the "kitchen sink" problem that plagues OLS with large predictor sets.
Academic research on Phillips-curve specification uses LASSO to adjudicate among competing slack measures.Stock and Watson (2019) included unemployment, output gap, capacity utilization, and various labor-market indicators (with lags) as candidates. LASSO's selection reveals which measures contain independent forecasting power for inflation after accounting for the others---a question that generates long debates when addressed by eyeball comparison of in-sample fit.
In financial economics, LASSO identifies which of hundreds of firm characteristics predict stock returns in the cross-section. Gu, Kelly, and Xiu (2020) used LASSO (among other ML methods) on a large set of firm-level predictors, finding that 20--30 characteristics survive regularization. This approach has replaced ad hoc "anomaly" testing in much of the recent empirical asset pricing literature.
LASSO breaks down in three settings. First, when predictors are highly correlated, selection is unstable: LASSO picks one from a correlated group and discards the others, and which one it picks can change with minor data revisions. Elastic net fixes this by adding an L2 penalty that encourages correlated predictors to share weight. Second, LASSO can select at most min(n,p) variables. In extreme high-dimensional settings (p≫n), this cap binds before all true predictors are captured. Third, LASSO coefficients are biased toward zero by construction. Post-LASSO OLS---running OLS on the LASSO-selected variables---corrects the bias but introduces a two-stage procedure whose statistical properties are harder to characterize.